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PREVIOUS DIAGNOSTIC DEFINITIONS There have been many previous attempts to standardise criteria for diagnosis of ME/CFS
Principal among these have been the following:
U.S. CDC 1988 (Holmes)
- 6 months duration of fatigue
- Functional activity - 50% decrease in activity
- Six or eight symptoms required; physical symptoms sometimes required
- Neuropsychiatric symptoms - may be present
- New onset required
Exclusions: Extensive list of known physical causes, psychosis, bipolar disorder, substance abuse
U.S. CDC 1994 (Fukuda)
- 6 months duration of fatigue
- Substantial functional impairment
- Four symptoms required
- Cognitive or neuropsychiatric symptoms may be present
- New onset required
Exclusions: Clinically important medical conditions, melancholic depression, substance abuse, bipolar disorder, psychosis, eating disorders
Australia 1990 (Lloyd)
- 6 months duration of fatigue
- Substantial functional impairment - disruption of daily activities
- Postexertional fatigue
- No symptoms specified
- New onset not required
Exclusions: Known physical causes, psychosis, bipolar disorder, substance abuse, eating disorders
Oxford 1991 (Sharpe)
- 6 months duration of fatigue
- Disabling functional impairment - affects physical and mental functioning
- No symptoms specified
- Cognitive or neuropsychiatric symptoms may be present
- Definite onset required
Exclusions: Known physical causes, psychosis, bipolar disorder, eating disorders, Organic brain disease, substance abuse. Other psychiatric disorders (depressive illness, anxiety disorders) are not reasons for exclusion
London 1990 (Dowsett et al)
- Complaint of general or local muscular fatigue following minimal exertion with prolonged recovery time
- Neurological disturbance, especially of cognitive, autonomic and sensory functions
- Variable involvement of cardiac and other systems, a prolonged relapsing course
- Syndrome commonly initiated by respiratory and/or gastrointestinal infection but an insidious or more dramatic onset after neurological, cardiac, or endocrine disability
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